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Lisa Ryan

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Clinic for Rheumatic Diseases

Phone

(205) 750-0030

Address

4280 WATERMELON RD STE 112, Northport AL

ZIP Code

35473

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PrismRA is a molecular signature response classifier (MSRC) that uses gene expression features, clinical features and anti-cyclic citrullinated protein (anti-CCP) antibody to detect a signature of non-response to tumor necrosis factor-α inhibitors (TNFi) for patients with rheumatoid arthritis. PrismRA predicts the patient’s likelihood of inadequately responding to all TNFi therapies. Response is defined as achieving ACR50 at 6 months. The PrismRA result is reported on a continuous 1 to 25 scale. The higher the score, the more likely the patient will have an inadequate response to TNFi therapies; the lower the score, the less likely the patient will have an inadequate response to TNFi therapies. However, a low score does not ensure a positive response to TNFi therapies.

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